NASDAQ · TSHAHealthcareBiotechnology

Taysha Gene Therapies, Inc. Common Stock (TSHA)

$4.36+6.60%
Close Nov 4, 2026 · split-adjusted
Oct 30, 2026$4.13▼ 7.40% in range
Nov 3, 2025Low $3.51 · High $6.98Oct 30, 2026
What changed · written from our data
As of Nov 4, 2026

Taysha Gene Therapies closed at $4.36 on Nov 4, up 6.60%, 37.5% below its 52-week closing high. Volume of 4.0M shares was 1.05× its 20-day average (close to normal).

Split-adjusted performance: -0.7% over one month, -37.5% over six months, -2.2% over one year.

Short interest was 51.2M shares at the Oct 15 settlement, down 6.9% from the prior report (17.6% of float, 11.6 days to cover).

Market cap$1.42B325.8M shares
Revenue · quarter$0.00−100.0% YoY
Diluted EPS$-0.13—
P/E · TTM—P/S 259.0×
Net margin—
Dividend yieldNone
52-week range3.51 – 6.98−37.5% from high
Volume4.0M1.05× 20-day avg
Volatility · 60d58.8%Annualised
Short % of float17.6%11.6 days to cover
Net cash$406.1MCash $455.4M
Next earnings—Not scheduled
Split-adjusted performance
1W +3.1%1M −0.7%3M −31.2%6M −37.5%YTD −20.7%1Y −2.2%3Y +92.9%5Y −73.0%

Earnings reactions

History →

No reported quarters with price history yet.

Rank within Biotechnology

Percentile among 139 companies (100 = best)

6-month momentum38
Revenue growth3
Net margin—
Value (low P/E)—
Size75

Industry medians: 6-month return −19.2%, revenue growth +8.8%, net margin −312.9%, P/E 22.0×.

Short interest

Details →
Shares short51.2M−6.9% vs prior
Days to cover11.6Settled Oct 15
% of float17.6%
Short vol. 10d66.6%of daily volume

Closest peers by size in Biotechnology

CompanyPriceToday6MRev. growthNet marginP/EMkt cap
TSHATaysha Gene Therapies$4.36+6.60%−37.5%−100.0%——$1.42B
INBXInhibrx Biosciences$86.76+7.01%−38.8%−100.0%——$1.28BCompare
VORVor Biopharma$20.12+1.31%+26.5%——0.9$1.24BCompare
NVAXNovavax$10.65+10.02%+13.8%−76.3%−94.2%—$1.76BCompare
MAZEMaze Therapeutics$33.38+3.50%+26.1%———$1.85BCompare
REPLReplimune Group$20.69+0.19%+501.5%———$1.96BCompare
VIRVir Biotechnology$11.77+4.90%+14.4%+19582.5%33.5%—$1.99BCompare
BCRXBioCryst Pharmaceuticals$8.24−3.85%−6.7%+33.6%35.9%—$2.11BCompare
COAGHemab Therapeutics Holdings$45.09+4.62%————$2.11BCompare

Quick answers

What does Taysha Gene Therapies do?
Taysha Gene Therapies Inc is a clinical-stage biotechnology company focused on advancing AAV-based gene therapies for the treatment of severe monogenic diseases of the central nervous system, or CNS. The company's clinical program TSHA-102 is in development for the treatment of Rett syndrome, a rare neurodevelopmental disorder with no approved disease-modifying therapies that address the genetic root cause of the disease.
What is TSHA's market cap?
$1.42B, based on the Nov 4 close of $4.36.
Does Taysha Gene Therapies pay a dividend?
No regular cash dividend has been paid in the last year.
How much of TSHA is sold short?
51.2M shares, 17.6% of float, as of Oct 15, 2026.
What sector is TSHA in?
Healthcare, in the Biotechnology industry.

About Taysha Gene Therapies

Taysha Gene Therapies Inc is a clinical-stage biotechnology company focused on advancing AAV-based gene therapies for the treatment of severe monogenic diseases of the central nervous system, or CNS. The company's clinical program TSHA-102 is in development for the treatment of Rett syndrome, a rare neurodevelopmental disorder with no approved disease-modifying therapies that address the genetic root cause of the disease. The Company views its operations and manages its business as a single operating segment, the gene therapy segment, which is the business of developing AAV-based gene therapies for the treatment of rare monogenic diseases of the central nervous system.

HQ: Dallas, TX99 employeesListed Sep 24, 2020tayshagtx.com

Sources: Massive / Polygon daily aggregates (split-adjusted) · SEC filings via Massive · FINRA settlements via Massive · Financial Modeling Prep. Figures are dated where shown; research is informational, not investment advice. Methodology