NASDAQ · MAZEHealthcareBiotechnology

Maze Therapeutics, Inc. Common Stock (MAZE)

$33.38+3.50%
Close Nov 4, 2026 · split-adjusted
Nov 4, 2026$33.35▲ 0.33% in range
Nov 3, 2025Low $22.39 · High $51.84Nov 4, 2026
What changed · written from our data
As of Nov 4, 2026

Maze Therapeutics closed at $33.38 on Nov 4, up 3.50%, 35.6% below its 52-week closing high. Volume of 536.6K shares was 0.71× its 20-day average (below normal).

Split-adjusted performance: +26.3% over one month, +26.1% over six months, +0.4% over one year.

Short interest was 7.5M shares at the Oct 15 settlement, up 14.7% from the prior report (18.8% of float, 10.1 days to cover).

Market cap$1.85B55.5M shares
Revenue · quarter$0.00—
Diluted EPS$-0.76—
P/E · TTM—P/S 92.7×
Net margin—
Dividend yieldNone
52-week range22.39 – 51.84−35.6% from high
Volume536.6K0.71× 20-day avg
Volatility · 60d67.7%Annualised
Short % of float18.8%10.1 days to cover
Net cash$372.1MCash $411.1M
Next earnings—Not scheduled
Split-adjusted performance
1W +5.2%1M +26.3%3M +17.0%6M +26.1%YTD −19.4%1Y +0.4%3Y —5Y —

Earnings reactions

History →

No reported quarters with price history yet.

Rank within Biotechnology

Percentile among 139 companies (100 = best)

6-month momentum81
Revenue growth—
Net margin—
Value (low P/E)—
Size76

Industry medians: 6-month return −19.2%, revenue growth +8.8%, net margin −312.9%, P/E 22.0×.

Short interest

Details →
Shares short7.5M+14.7% vs prior
Days to cover10.1Settled Oct 15
% of float18.8%
Short vol. 10d58.2%of daily volume

Closest peers by size in Biotechnology

CompanyPriceToday6MRev. growthNet marginP/EMkt cap
MAZEMaze Therapeutics$33.38+3.50%+26.1%———$1.85B
NVAXNovavax$10.65+10.02%+13.8%−76.3%−94.2%—$1.76BCompare
REPLReplimune Group$20.69+0.19%+501.5%———$1.96BCompare
VIRVir Biotechnology$11.77+4.90%+14.4%+19582.5%33.5%—$1.99BCompare
BCRXBioCryst Pharmaceuticals$8.24−3.85%−6.7%+33.6%35.9%—$2.11BCompare
COAGHemab Therapeutics Holdings$45.09+4.62%————$2.11BCompare
RXRXRecursion Pharmaceuticals$3.88+5.43%+13.1%+258.5%−641.6%—$2.32BCompare
VCELVericel$45.48+10.68%+23.7%+22.5%2.8%96.2$2.33BCompare
ADMAADMA Biologics$10.48−5.67%+4.0%+2.0%30.4%13.9$2.35BCompare

Quick answers

What does Maze Therapeutics do?
Maze Therapeutics Inc is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small-molecule precision medicines for patients living with renal, cardiovascular, and related metabolic, or CVRM, diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows the company to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization.
What is MAZE's market cap?
$1.85B, based on the Nov 4 close of $33.38.
Does Maze Therapeutics pay a dividend?
No regular cash dividend has been paid in the last year.
How much of MAZE is sold short?
7.5M shares, 18.8% of float, as of Oct 15, 2026.
What sector is MAZE in?
Healthcare, in the Biotechnology industry.

About Maze Therapeutics

Maze Therapeutics Inc is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small-molecule precision medicines for patients living with renal, cardiovascular, and related metabolic, or CVRM, diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows the company to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. It is currently advancing two programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease, or CKD.

HQ: South San Francisco, CA141 employeesListed Jan 31, 2025mazetx.com

Sources: Massive / Polygon daily aggregates (split-adjusted) · SEC filings via Massive · FINRA settlements via Massive · Financial Modeling Prep. Figures are dated where shown; research is informational, not investment advice. Methodology