NASDAQ · PRAXHealthcarePharmaceuticals

Praxis Precision Medicines, Inc. Common Stock (PRAX)

$284.79+1.53%
Close Nov 4, 2026 · split-adjusted
Nov 4, 2026$284.79▲ 65.82% in range
Nov 4, 2025Low $164.09 · High $386.33Nov 4, 2026
What changed · written from our data
As of Nov 4, 2026

Praxis Precision Medicines closed at $284.79 on Nov 4, up 1.53%, 26.3% below its 52-week closing high. Volume of 372.9K shares was 0.74× its 20-day average (below normal).

Split-adjusted performance: +1.7% over one month, -15.8% over six months, +56.5% over one year.

Short interest was 3.9M shares at the Oct 15 settlement, down 6.4% from the prior report (14.1% of float, 7.4 days to cover).

Market cap$7.95B27.9M shares
Revenue · quarter$0.00—
Diluted EPS$-2.87—
P/E · TTM—
Net margin—
Dividend yieldNone
52-week range164.09 – 386.33−26.3% from high
Volume372.9K0.74× 20-day avg
Volatility · 60d48.5%Annualised
Short % of float14.1%7.4 days to cover
Net cash$758.6MCash $758.6M
Next earnings—Not scheduled
Split-adjusted performance
1W −0.2%1M +1.7%3M −23.1%6M −15.8%YTD −3.4%1Y +56.5%3Y +1770.5%5Y −12.4%

Earnings reactions

History →

No reported quarters with price history yet.

Rank within Pharmaceuticals

Percentile among 420 companies (100 = best)

6-month momentum60
Revenue growth—
Net margin—
Value (low P/E)—
Size93

Industry medians: 6-month return −25.5%, revenue growth +6.2%, net margin −33.8%, P/E 16.1×.

Short interest

Details →
Shares short3.9M−6.4% vs prior
Days to cover7.4Settled Oct 15
% of float14.1%
Short vol. 10d71.0%of daily volume

Closest peers by size in Pharmaceuticals

CompanyPriceToday6MRev. growthNet marginP/EMkt cap
PRAXPraxis Precision Medicines$284.79+1.53%−15.8%———$7.95B
ALKSAlkermes$45.89+0.44%+29.9%+21.8%3.4%—$7.70BCompare
RYTMRhythm Pharmaceuticals$110.68+28.04%+14.6%+46.9%−70.7%—$7.62BCompare
KNSAKiniksa Pharmaceuticals International$96.12+3.03%+65.1%+58.1%16.6%68.9$7.55BCompare
CORTCorcept Therapeutics$79.22−3.31%+51.9%+31.7%16.8%157.2$8.56BCompare
ARWRArrowhead Research$61.65+3.56%−22.1%+171.0%−258.2%—$8.71BCompare
AXSMAxsome Therapeutics$137.00−1.87%−38.5%+51.9%−5.0%—$7.18BCompare
CYTKCytokinetics$63.60+2.07%−15.0%−57.1%−694.4%—$8.84BCompare
AMRXAmneal Pharmaceuticals$19.95−1.29%+46.5%+9.9%7.2%44.2$6.95BCompare

Quick answers

What does Praxis Precision Medicines do?
Praxis Precision Medicines Inc is a clinical-stage biopharmaceutical company. It is engaged in translating genetic insights into the development of therapies for patients affected by central nervous system disorders characterized by a neuronal excitation-inhibition imbalance.
What is PRAX's market cap?
$7.95B, based on the Nov 4 close of $284.79.
Does Praxis Precision Medicines pay a dividend?
No regular cash dividend has been paid in the last year.
How much of PRAX is sold short?
3.9M shares, 14.1% of float, as of Oct 15, 2026.
What sector is PRAX in?
Healthcare, in the Pharmaceuticals industry.

About Praxis Precision Medicines

Praxis Precision Medicines Inc is a clinical-stage biopharmaceutical company. It is engaged in translating genetic insights into the development of therapies for patients affected by central nervous system disorders characterized by a neuronal excitation-inhibition imbalance. The company applies genetic insights to the discovery and development of therapies for neurological disorders through two proprietary platforms: Cerebrum and Solidus. It has established a diversified, multimodal CNS portfolio with four clinical-stage product candidates across movement disorders and epilepsy, which include Ulixacaltamide, Relutrigine, Vormatrigine, and Elsunersen. The firm operates in only one segment and is focused on discovering and developing therapies for CNS disorders.

HQ: Boston, MA10,998 employeesListed Oct 16, 2020praxismedicines.com

Sources: Massive / Polygon daily aggregates (split-adjusted) · SEC filings via Massive · FINRA settlements via Massive · Financial Modeling Prep. Figures are dated where shown; research is informational, not investment advice. Methodology