NASDAQ · SPTXHealthcarePharmaceuticals

Seaport Therapeutics, Inc. Common Stock (SPTX)

$20.39−2.72%
Close Nov 5, 2026 · split-adjusted
Nov 5, 2026$20.09▼ 13.95% in range
Sep 11, 2026Low $16.08 · High $24.70Nov 5, 2026
What changed · written from our data
As of Nov 5, 2026

Seaport Therapeutics closed at $20.39 on Nov 5, down 2.72%, 17.4% below its highest close since Sep 11. Volume of 221.1K shares was 0.93× its 20-day average (close to normal).

Split-adjusted performance: +13.7% over one month.

Short interest was 3.7M shares at the Oct 15 settlement, up 1.9% from the prior report (19.2% of float, 17.9 days to cover).

Market cap$1.09B53.5M shares
Revenue · quarter$0.00—
Diluted EPS$-0.49—
P/E · TTM—
Net margin—
Dividend yieldNone
Range since Sep 1116.08 – 24.70−17.4% from high
Volume221.1K0.93× 20-day avg
Volatility · 60d—Annualised
Short % of float19.2%17.9 days to cover
Net cash$290.4MCash $290.4M
Next earnings—Not scheduled
Split-adjusted performance
1W −3.4%1M +13.7%3M —6M —YTD —1Y —3Y —5Y —

Earnings reactions

History →

No reported quarters with price history yet.

Rank within Pharmaceuticals

Percentile among 420 companies (100 = best)

6-month momentum—
Revenue growth—
Net margin—
Value (low P/E)—
Size72

Industry medians: 6-month return −28.4%, revenue growth +5.9%, net margin −38.9%, P/E 15.0×.

Short interest

Details →
Shares short3.7M+1.9% vs prior
Days to cover17.9Settled Oct 15
% of float19.2%
Short vol. 10d83.2%of daily volume

Closest peers by size in Pharmaceuticals

CompanyPriceToday6MRev. growthNet marginP/EMkt cap
SPTXSeaport Therapeutics$20.39−2.72%————$1.09B
VSTMVerastem$9.38−4.77%+65.7%+1775.4%−86.5%—$1.14BCompare
MRVIMaravai LifeSciences Holdings$6.98−9.59%+77.2%+8.5%−24.1%—$1.04BCompare
AMPHAmphastar Pharmaceuticals$27.66−1.28%+15.1%+5.4%16.5%15.0$1.18BCompare
AVLNAvalyn Pharma$26.67−2.91%————$1.18BCompare
MNKDMannkind$3.76−4.33%+5.9%+42.9%−17.4%—$1.21BCompare
JANXJanux Therapeutics$16.06−11.66%+10.5%—−214.0%—$981.9MCompare
HROWHarrow$26.04−9.43%−33.3%+10.9%−24.4%—$976.2MCompare
LBRXLB Pharmaceuticals$38.09−6.76%+19.1%———$1.23BCompare

Quick answers

What does Seaport Therapeutics do?
Seaport Therapeutics Inc is a clinical-stage therapeutics company. The company focuses on invention and development of new medicines for patients with depression, anxiety, and other debilitating neuropsychiatric disorders.
What is SPTX's market cap?
$1.09B, based on the Nov 5 close of $20.39.
Does Seaport Therapeutics pay a dividend?
No regular cash dividend has been paid in the last year.
How much of SPTX is sold short?
3.7M shares, 19.2% of float, as of Oct 15, 2026.
What sector is SPTX in?
Healthcare, in the Pharmaceuticals industry.

About Seaport Therapeutics

Seaport Therapeutics Inc is a clinical-stage therapeutics company. The company focuses on invention and development of new medicines for patients with depression, anxiety, and other debilitating neuropsychiatric disorders. The company identified clinically validated mechanisms with established efficacy and safety profiles, historically limited by high first-pass metabolism, low bioavailability, and side effects. The company's pipeline products are based on Glyph, company's lymphatic-targeting prodrug technology is designed to bypass first-pass metabolism and thereby enhance a drug's oral bioavailability and reduce side effects.

HQ: Boston, MAListed May 1, 2026seaporttx.com

Sources: Massive / Polygon daily aggregates (split-adjusted) · SEC filings via Massive · FINRA settlements via Massive · Financial Modeling Prep. Figures are dated where shown; research is informational, not investment advice. Methodology