NASDAQ · APREHealthcarePharmaceuticals

Aprea Therapeutics, Inc. Common stock (APRE)

$0.5150+4.89%
Close Nov 3, 2026 · split-adjusted
Oct 30, 2026$0.48▼ 65.39% in range
Oct 31, 2025Low $0.45 · High $1.40Oct 30, 2026
What changed · written from our data
As of Nov 3, 2026

Aprea Therapeutics closed at $0.52 on Nov 3, up 4.89%, 63.2% below its 52-week closing high. Volume of 64.0K shares was 0.36× its 20-day average (below normal).

Split-adjusted performance: -23.8% over one month, -38.9% over six months, -63.2% over one year.

Short interest was 621.2K shares at the Oct 15 settlement, up 22.1% from the prior report (5.9% of float, 2.2 days to cover).

Market cap$6.5M12.6M shares
Revenue · quarter$0.00−100.0% YoY
Diluted EPS$-0.07—
P/E · TTM—P/S 1,250.6×
Net margin—
Dividend yieldNone
52-week range0.45 – 1.40−63.2% from high
Volume64.0K0.36× 20-day avg
Volatility · 60d96.0%Annualised
Short % of float5.9%2.2 days to cover
Net cash$41.2MCash $41.2M
Next earnings—Not scheduled
Split-adjusted performance
1W +0.4%1M −23.8%3M −17.1%6M −38.9%YTD −39.6%1Y −63.2%3Y −85.4%5Y −99.5%

Earnings reactions

History →

No reported quarters with price history yet.

Rank within Pharmaceuticals

Percentile among 420 companies (100 = best)

6-month momentum33
Revenue growth1
Net margin—
Value (low P/E)—
Size10

Industry medians: 6-month return −26.5%, revenue growth +6.4%, net margin −38.1%, P/E 16.4×.

Short interest

Details →
Shares short621.2K+22.1% vs prior
Days to cover2.2Settled Oct 15
% of float5.9%
Short vol. 10d34.6%of daily volume

Closest peers by size in Pharmaceuticals

CompanyPriceToday6MRev. growthNet marginP/EMkt cap
APREAprea Therapeutics$0.5150+4.89%−38.9%−100.0%——$6.5M
XCURExicure$1.01−0.98%−70.3%———$6.6MCompare
NAIINatural Alternatives International$1.06−0.93%−59.4%+1.9%−39.2%—$6.6MCompare
CNSPCNS Pharmaceuticals$4.55+3.64%−36.4%———$6.6MCompare
ENVBEnveric Biosciences$1.50+3.45%−56.9%———$6.7MCompare
FBLGFibroBiologics$0.9900+7.60%−25.6%———$7.0MCompare
ALZNAlzamend Neuro$1.46+16.80%+36.4%———$7.0MCompare
ENSCEnsysce Biosciences$0.3777−1.15%−5.6%−15.1%−220.8%—$7.3MCompare
LGVNLongeveron$1.78+4.09%−79.2%−9.2%−2116.0%—$5.7MCompare

Quick answers

What does Aprea Therapeutics do?
Aprea Therapeutics Inc is a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers. It develops small molecule inhibitors designed to exploit genetic mutations in cancer to widen the therapeutic window and is intended to make treatments more effective at destroying cancer cells while sparing healthy tissue.
What is APRE's market cap?
$6.48M, based on the Nov 3 close of $0.52.
Does Aprea Therapeutics pay a dividend?
No regular cash dividend has been paid in the last year.
How much of APRE is sold short?
621.2K shares, 5.9% of float, as of Oct 15, 2026.
What sector is APRE in?
Healthcare, in the Pharmaceuticals industry.

About Aprea Therapeutics

Aprea Therapeutics Inc is a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers. It develops small molecule inhibitors designed to exploit genetic mutations in cancer to widen the therapeutic window and is intended to make treatments more effective at destroying cancer cells while sparing healthy tissue. The company's pipeline of clinical and preclinical programs includes APR-1051, a WEE1 inhibitor; ATRN-119 (Mosipasertib), an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related, or ATR; and an early-stage program, APR-1602. These candidates are being developed for broad applications in cancer treatment.

HQ: Doylestown, PA8 employeesListed Oct 3, 2019aprea.com

Sources: Massive / Polygon daily aggregates (split-adjusted) · SEC filings via Massive · FINRA settlements via Massive · Financial Modeling Prep. Figures are dated where shown; research is informational, not investment advice. Methodology